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OCTN2 (novel organic cation 2, SLC22A5), is the primary transporter responsible for high-affinity uptake of carnitine and is highly expressed in tissues with high rates of fatty acid metabolism such as heart, skeletal muscle and brain 3,4

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Acetylcarnitine also has potential regulatory effects on pain perception and emotion regulation by increasing the level of acetylated H3K27 bound to the Grm2 promoter through the epigenetic regulation of the type 2 metabotropic glutamate (mGlu2) receptor, as well as the acetylation of the NF-B p65 subunit by increasing the transcription of the Grm2 gene [40, 41]