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Theriogenology 158, 477489

During the repair phase of late inflammation, M1 macrophages polarize toward M2 macrophages, secreting anti-inflammatory factors (including IL-4, IL-10, IL-13 and TGF-) to inhibit the inflammatory response and facilitate tissue repair and remodeling (Fig

Leveraging this strategy, the same group designed a method to generate a C-terminal ubiquitin (Ub) aldehyde from Thz-caged Ub using a Pd-mediated cleavage reaction, resulting in the inhibition of cellular deubiquitinases (DUBs) that exclusively cleave the isopeptide bond between Ub and a protein substrate 72

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