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Interleukin-6 in acute inflammation The acute phase response includes changes in the concentrations of many plasma proteins, which are known as the acute phase proteins (Figure 1), as well as numerous behavioural, physiological, biochemical and nutritional changes [4]

Given that Chac1 overexpressionmediated glutathione depletion substantially suppresses lipogenesis and mitigates MASLD/MASH progression, we asked whether Chac1 expression is regulated during normal metabolic transitions or in liver disease states

Flow cytometry and sorting For surface staining cells were incubated at 48 C, in the dark with fluorochrome-conjugated CD19, CD23, CD21-CD35 or CD35, IgD, IgM, CD1d, CD24, CD93, CD95, and GL-7 diluted 1:200 (refer to Supplementary Data 4 for details)

The advantages of saRNA over mRNA in protein replacement therapy are significant, including higher protein expression levels and prolonged half-life