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In another study, it has examined the effects of Hg on neurobehavioral and neurochemical disorders in mouse offspring where CUR increased the levels of cerebral monoamines (dopamine, norepinephrine, and serotonin) in Hg-treated pups

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The data suggested that release of the cysteine moiety of GSH is critical for the restoration of transcriptional response to cystine starvation, which corroborated the signaling result of p-GCN, p-eIF2 and notably ATF4, which induces the expression of genes containing AARE (Fig