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Preferably, the two entities are conjugated by non-specific or specific protein- protein interaction, by covalent bonding, by non-covalent bonding, by coordinating chemical bonding, by chemical synthesis, either directly or via a (non)cleavable spacers, linkers or components of nanocontainers, or by recombinant technologies

Lindsley CW, Niswender CM, Engers DW, Hopkins CR (2009)

61 Moreover, Notch signaling suppressed chondrocyte proliferation in the growth plate apparently independent of RBPjk while it also promoted both the onset and terminal progression of chondrocyte hypertrophy in a RBPjk dependent manner

Beyond classical apoptosis, necroptosis (Luo C.-H