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As we age or experience chronic stress, this software can become corruptedpro-inflammatory genes may become overactive, while genes responsible for repair and antioxidant defense become suppressed
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This ATP-depleting futile 5-oxoproline cycle was first proposed by Kumar and Bachhawat to explain the development of Fanconi syndrome, ATP depletion, and 5-oxoprolinuria in children with nephropathic cystinosis (38,39)

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