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IGF-I stimulates proliferation of various tissues including chondrocytes (cartilage cells), muscles cells, and bone cells resulting in bone growth

Furthermore, NPs can be engineered to mimic endogenous transport mechanisms, like those used by nutrients or hormones, to cross the BBB more effectively (22)

In liver cirrhosis lower IGF-1 concentrations were observed in comparison with control (99,100), as well as its increased concentration following anti-viral therapy (100)

Experimental data suggest that the peptide acts as a ghrelin-like signaling molecule, influencing pathways that regulate hormone release from the pituitary gland