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Description
Include leptin-deficient cohorts if mechanistic generalizability is a goal

Since GH secretion declines progressively and markedly with aging, and many age-related changes resemble those of partial adult-onset GHD, stimulating production and secretion of endogenous GH with GH-releasing hormone (GHRH) or its analog Sermorelin, a GH secretagogue, could confer benefits in normal aging similar to those observed in AGHD

doi: 10.1097/MD.0000000000037326 84 ChengF-K

Shah RR, Bird AP
