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It helps the body turn food into glucose, which gives us energy

This manifests as genomic instability through the accumulation of mutagenic lesions like 8-oxoguanine (8-oxoG), which drives both disease risk and progression by acting as an epigenetic-like mark [230, 231]

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The structural alteration of TopoI and cellular response alterations in CPT-DNA-ternary complex formation are the 2 factors in drug resistence 204
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