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Description
MM a 46 year old man with recurring episodes of chest pain and syncope requiring emergency room evaluation on 5 occasions over the previous year

225-227 Importantly, age-related hearing loss has been identified as one of the most modifiable risk factors for dementia

To ascertain a comprehensive role of the UPR in cystine uptake inhibition-induced ferroptosis, we examined the status of the three canonical UPR pathways: (1) IRE1-XBP1s, (2) PERK-ATF4-eIF2 and (3) ATF6 in both MDA-MB-231 and Panc-1 cells upon erastin treatment or cystine starvation

Prioritizing these questions is essential to move beyond descriptive phenomenology and towards the rational design of therapeutic strategies that can reliably steer this dynamic crosstalk toward tumor eradication
