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J., et al., Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study)

The intestines regulate Mn through both absorption and excretion, which is controlled by specific transporters localized on the apical (lumen-facing) and basolateral (blood-facing) membranes of the intestinal epithelium (Figure 1A)

Furusawa and colleagues found that butyrate produced by obligate anaerobic bacteria improved colitis by promoting histone H3 acetylation in the promoter and conserved non-coding sequence regions of the Foxp3 locus, thereby supporting differentiation of T reg cells and enhancing intestinal immune tolerance (84)

Now it is necessary to conduct research for the genetic improvement of this plant