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It could therefore be that measured concentration levels are confounded or masked by these basic metabolic processes and in consequence the signal-to-noise ratio of our analysis might be lowered with respect to the targeted pathological differences in concentrations
In addition, impaired mitochondrial biogenesis leading to inadequate energy supply and neuronal damage has been observed in neurological disorders
doi: 10.1056/NEJMoa1707914 118 RostagnoAA
