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This review will focus on the conditioning regimen, which serves the purposes of disease eradication, bone marrow (BM) depletion to create space for donor cells, and to reduce immune-driven rejection [3]

In the early-peaked studies, Hansson et al

cGASSTING pathwaycytosolic DNA sensing The discovery of the cGASSTING pathway has fundamentally reshaped our understanding of how cells detect cytosolic DNA as a danger signal, establishing a direct molecular link between mitochondrial injury and innate immunity [96,97,98]

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