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Qin CX, May LT, Li R, Cao N, Rosli S, Deo M, et al
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The present study also examined cell viability and LDH release levels
Following interaction of pVHL, additional proteins are recruited that includes elongin C, elongin B, RBX1 (ring-box 1), cullin-2, and an E2 ubiquitin-conjugating enzyme forming a ubiquitin E3 ligase complex resulting in ubiquitylation of the HIF -subunit and its subsequent degradation in the proteasome
