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doi: 10.3389/fimmu.2013.00324 Received 16 July 2013 Accepted 24 September 2013 Published 11 October 2013 Volume 4 - 2013 Edited by Gergely Toldi, Semmelweis University, Hungary Reviewed by Tomasz Zal, University of Texas MD Anderson Cancer Center, USA

Chemical Makeup (3)(4) Molecular Formula Tesamorelin: C 221 H 366 N 72 O 67 S Ipamorelin: C 38 H 49 N 9 O 5 Molecular Weight Tesamorelin: 5136 g/mol Ipamorelin: 711.8 g/mol Sequence Tesamorelin: Unk-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2 Ipamorelin: H-Aib-His-D-2Nal-D-Phe-Lys-NH2 Other Known Titles Tesamorelin: (3E)-hex-3-enoylsomatoliberin Ipamorelin: Ipamorelin Acetate, Aib-His-D-2-Nal-D-Phe-Lys-NH2 Research and Clinical Studies Tesamorelin & Ipamorelin Blend and Growth Hormone Deficiency The Tesamorelin and Ipamorelin blend appears to exert its potential through distinct yet complementary proposed mechanisms of action

Adenovirus expression of PON-2 and PON-3 also inhibits atherosclerosis in Apoe -/- mice (433,434), indicating that all three PON enzymes have protective effects