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A few things that may play a role are: Your genes
This may be important since without therapy, the occluded superior sagittal sinus rapidly provoked a particular syndrome, the severe brain disturbances, brain swelling and lesions (i.e., confluent infarction encompassing most of the cerebral cortex) and highly increased positive pressure values and thrombosis in the superior sagittal sinus

This is crucial for multi-use vials as it prevents bacterial contamination after the rubber stopper has been punctured multiple times

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