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In the isoproterenol-induced CKD mouse model, supplementation of IMC reduced the level of TMA and TMAO by selectively inhibiting the TMA lyase activity of the gut microbiota, consequently ameliorating tubulointerstitial fibrosis (TIF) induced by choline diet, and improving renal function damage

Most of the existing preclinical research indicates that PEA works by changing the expression of certain genes and reducing inflammatory signaling, but other possible mechanisms for its analgesic effect have also been proposed, including its ability to stimulate signaling through cannabinoid receptors in the nervous system (Gabrielsson 2016