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PARP or ATM/ATR inhibitors may increase genomic instability in normal tissues due to off-target effects, with long-term PARP inhibitor use potentially inducing hematopoietic malignancies and ATR inhibitors exhibiting hepatotoxicity in mouse models (196,204,211,212)

Following the ' 'manufacturer's instructions, the isolates were classified using the standard examination of their morphological characteristics, biochemical responses, an API 20NE test kit (bioM'erieux, Marcy lEtoile, France), and the VITEK C15 automated system for identifying bacteria (BioMerieux Inc., France)

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