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Description
JASN 31 (5), 907919
J Cell Biol 183:795803
Thus, NCOA4 is recognized as a facilitator of ferroptosis, while HERC2 (an E3 ubiquitin ligase for NCOA4 and FBXL5), VAMP8 (involved in autophagosome-lysosome fusion), and C-MYC have the potential to influence ferritin autophagy by modulating NCOA4 expression
The FTCD gene is located on chromosome 21q22.3 and is composed of 16 exons that generate three alternatively spliced mRNAs, two of which encode the same 541 amino acid protein (isoform A) and the other encodes a protein of 572 amino acids (isoform C)
