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Firstly, the role of IGF-1 signaling in the modulation of anabolic effects of parathyroid hormone (PTH) on bone will be discussed, presenting in vitro and in vivo studies that establish this concept and the proposed underlying molecular mechanisms involving Indian hedgehog (Ihh) and the ephrins

doi: 10.1093/humupd/dmab046 102 HammoudSSNixDAHammoudAOGibsonMCairnsBRCarrellDT

The resulting product, DOPAL, is further metabolized to either 3,4-dihydroxyphenylacetic acid (DOPAC) or 3,4-dihydroxyphenylethanol (DOPET) by either aldehyde dehydrogenase (ALDH) or by aldehyde/aldose reductase (ALR/AR), respectively

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