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As of mid-2024, there are five DOACs approved for use in the United States: Betrixaban (Bevyxxa) Rivaroxaban (Xarelto) Apixaban (Eliquis) Edoxaban (Savaysa) Dabigatran (Pradaxa) The mechanism(s) by which DOACs work differ from those of two other common anticoagulants: Warfarin inhibits clotting by acting as a vitamin K antagonist, and Heparin/low-molecular weight heparin works by activating antithrombin, which inactivates the coagulation enzymes thrombin, factor Xa, and factor IXa

For patients with early-stage disease, survival rates are similar when comparing the two procedures

Epub 2010 Jul 21

Second, responsibility shifts onto the sponsor and the HREC