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This broad receptor engagement profile means that Melanotan II simultaneously activates melanogenic pathways (MC1R on melanocytes), appetite and energy homeostasis circuits (MC3R/MC4R in hypothalamus), and exocrine gland function pathways (MC5R), making it essential for researchers to design appropriate controls and selective antagonists into experimental protocols to attribute observed effects to specific receptor subtypes

3 Melanoma is one of the most immunogenic cancers, and there are several clinical immunotherapeutic trials currently being conducted to test the effects of various antitumor vaccines