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213 p62 and dipeptidyl peptidase 9 (DPP9) disrupt the interaction between KEAP1 and NRF2 by competitively binding to KEAP1 to maintain the NRF2 stability and promote the transcription of its downstream iron metabolism and antioxidant genes, resulting in ferroptosis-mediated sorafenib resistance

To increase the amount of vitamin B12 in your diet, eat more foods that contain it, such as: Beef, liver, and chicken Fish and shellfish such as trout, salmon, tuna, and clams Fortified breakfast cereal Low-fat milk, yogurt, and cheese Eggs Your doctor might recommend that you also take a vitamin B12 supplement

31 Mattie DR, Yamamoto D, LeGuin K, et al

Developing irreversible inhibitors of the protein kinase cysteinome