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Recent research shows that EGCG has therapeutic potential in various neurodegenerative disorders, with distinct mechanisms tailored to each conditions pathophysiology
Our analyses demonstrated that PD patients exhibit significant metabolic reprogramming, characterized by a shift in energy metabolism from the tricarboxylic acid cycle toward glycolysis, a dysregulated urea cycle, and lipid remodeling, as well as extensive activation of inflammatory and immune responses involving the PI3K-Akt, IL-17, NF-kappaB, MAPK and TNF signaling pathways
Next, 100 nl of compounds were transferred using a JANUS MDT Workstation (Revvity) and a 384-well pin tool (V&P Scientific)
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