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This can lead to severe side effects, including thrombocytopenia (low platelet count) and immune suppression, increasing the risk of infections.36 Long-term use of senolytics could potentially cause tissue damage, impaired wound healing, or unintended apoptosis in healthy cells.119 Lack of Senescent Cell-Specific Targets: One of the major challenges in senolytic therapy is ensuring the selective elimination of senescent cells without affecting healthy cells

Physiol., 254: F1-F8