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11 Women at high risk of or with known vitamin B 12 deficiency should supplement with vitamin B 12 while pregnant or breastfeeding

Additional risk factors include: Chronic kidney disease : Reduced renal clearance may impair B12 excretion Liver disease : Hepatic dysfunction can disrupt B12 metabolism and storage Myeloproliferative disorders : Certain blood cancers increase B12-binding proteins Concurrent medication use : Some drugs may interact with B12 metabolism, including metformin, proton pump inhibitors, and H2 antagonists Patients with these conditions should have B12 supplementation carefully monitored by their healthcare team

NNMT inhibition as a metabolic and epigenetic research target

Vitamin B12 is also a vital nutrient for brain development, both during pregnancy and in early infancy
