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[PubMed] [Google Scholar] 49.Nakagawa K, Eitsuka T, Inokuchi H, Miyazawa T
2018;17:e12699

However, the efficacy results did not show a significant benefit over comparator treatments, which led Merrimack to stop further trials of MM-302 in 2016

FIGURE 4 7 Conclusion Many in vitro , in vivo , and pre-clinical studies have demonstrated various effects of metformin, such as anti-diabetic, antioxidant, anti-inflammatory, anti-tumor, and cardioprotective effects in gynecological disorders, which are mainly due to the effects on the IGF system and several intracellular signaling transduction pathways, such as AMPK, PI3K/AKT/mTOR, and MAPK/ERK pathways
