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Description
Identification of a peptoid inhibitor of the proteasome 19S regulatory particle
Here, we reveal that the aldehyde derivative of UNC10088 promotes cooperative binding of FBXO22 to NSD2, a histone methyltransferase and oncogenic protein, leading to a cryo-EM structure of the SKP1-CUL1-F-box (SCF)-FBXO22 complex with NSD2

The plates were mixed using 1300 rpm (Heidolph Titramax 1000, #544-12200-00) and separated in the 96-well plate using a magnetic stand (Thermo Scientific, # AM10027)

(1) Encapsulation Efficiency (EE%) Encapsulation efficiency refers to the percentage of the active compound successfully entrapped within the liposomes relative to the total amount used
