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Fertil Steril 92, 541547 (2009)

In a 2020 paper called The Effect of Omega-3 Fatty Acids on Rheumatoid Arthritis, the authors reviewed decades of research on the impact of EPA and DHA on pain and inflammation in patients with rheumatoid arthritis

A anti-inflammatory assay via COX-2 inhibition in comparison with another standard Celecoxib (IC50 = 0.28 g/mL) suggested that the formulated nanoformulation is more potent than D-limonene alone with IC50 value 0.85 g/mL and 2.04 g/mL, respectively

When that does not happen, many assume the protocol is wrong, the dose is off, or TRT simply is not working for them
