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By combining the knowledge of p53 biology with immunotherapy, there is potential to revolutionize the design of p53-based cancer therapy in the future

Nat Rev Cancer 18(8):500510

Since these sensors employ a disulfide-sensing mechanism they cannot be used to determine absolute concentrations of GSH and GSSG, however, they respond to the redox potential of the glutathione buffer (that is to the [GSH] 2 /[GSSG] ratio) according to the relationship: The kinetic separation from the thioredoxin pathway ensures that the sensing is specific for the glutathione pool [90]

NAT deficiency may be the reason cats (and dogs) are more prone to acetaminophen-induced methemoglobinemia rather than hepatotoxicity