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As a consequence, the levels of intracellular cholesterol are reduced as cholesterol stored in cells as cholesterol esters is mobilized to replace that removed from the plasma membrane

Overexpressing the catalytically inactive variant of human HL was atheroprotective in chow-fed LDL receptorknockout mice lacking endogenous HL [13, 14], whereas no effect on atherosclerosis development was seen in the same model on a Western diet [12]

He was soon afterward arrested by the civil authority of the state, and committed to the jail at Goshen, Orange county, whence he escaped, and made his way through the country, in the disguise of a woman, to New York