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Both fall under WADA Code S0, the non-approved-substances category

FACT 5 OF 6 Check methylmalonic acid (MMA) for early detection MMA is a more sensitive marker than serum B12

Clinical studies typically use 600-1,800 mg/day in divided doses, with 600 mg once or twice daily being the most common supplemental protocol

The underlying mechanisms involve maladaptive auditory-limbic network connectivity and dysregulation of neuro-immune interactions, where astrocytes play a significant role in both neural responses to inflammation and the plasticity regulation implicated in tinnitus pathophysiology (Perin and Pizzala, 2024)