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Furthermore, expression of VAP-C was negligible in B cells prepared from chronic hepatitis C patients, in whom B cells included HCV particles (Ito et al., 2010), and expression of the full HCV genome in B cells induced B-cell lymphoma in a conditional transgenic mouse (Kasama et al., 2010), suggesting that HCV infection increases the chance of developing B-cell lymphomas via dysregulation of lipid metabolism