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doi: 10.1073/pnas.0702579104 216 KosKAslamMAvan de VenRWellensteinMDPietersWvan WeverwijkAet al

EFSA J 2011;9:2238

By depolarizing the membrane of pancreatic islets, melittin facilitates the opening of Ca + channels, allowing calcium ions to enter more easily and triggering B-cells to produce insulin (55, 8082)

We speculate that the hydrophobic nature of Spytag003 may have affected the solubility of the recombinant coat proteins to which it was inserted and consequently, the inability of the proteins to assemble to VLPs
