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In addition, hyperglycemia exacerbates neural injury and impedes repair by disrupting microvascular integrity, altering immune cell function, disturbing ionic homeostasis within nerves, and inducing Schwann cells (SCs) apoptosis along with impaired production of neurotrophic factors

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The analysis of an unsolved loop region near the proposed spermidine binding site revealed a new pocket that was demonstrated to bind glutathionylspermidine in an inverted orientation