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doi: 10.1016/j.ymthe.2021.09.015

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The binding of Keap 1, an adaptor protein for Cullin-3 (Cul3)/Ring box-1 (Rbx-1) E3 ubiquitin ligase complex, to Nrf2 leads to the ubiquitination and proteasome-dependent degradation of Nrf2 under basal conditions

Glutathione is crucial in helping the body neutralize chemicals in order to excrete them before they can wreak havoc, including inflammation
