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Glutathione deficiency can lower B12 levels because one of glutathiones roles is to protect B12 in the circulation
[DOI] [PMC free article] [PubMed] [Google Scholar] 380.Hecht F., Pessoa C.F., Gentile L.B., Rosenthal D., Carvalho D.P., Fortunato R.S

Glutathione also plays a role in processing medications and cancer-causing compounds (carcinogens), and building DNA, proteins, and other important cellular components

Additionally, ashwagandha is best taken in the evening because it can act as a sedative in large doses
