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These bursts mediate the rapid release of ROS such as hydrogen peroxide (H 2 O 2 ) and superoxide anion, which can be formed by the activity of superoxide dismutase

Conversely, VTA DA neurons, which are less vulnerable than SNpc DA neurons, generate broad spikes and are autonomous pacemakers, but have smaller Cav1 channel currents and a strong intrinsic calcium buffering by calbindin

Two of their top physicians both in apparently excellent health died of heart attacks

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