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For example, a mutation in the catalytic domain of Nox2 or in the domain responsible for interacting with the other NADPH subunits leads to a total loss of oxidative burst, whereas some mutations in the dehydrogenase domain have no effect on ROS production by phagocytes (Holland, 2013

[PubMed] [Google Scholar] 56.Tatsukawa H., Takeuchi T., Shinoda Y., Hitomi K

doi: 10.1007/s00424-017-2072-1

Journal of the American College of Cardiology
