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Abstract Systemic lupus erythematosus (SLE) patients exhibit depletion of the intracellular antioxidant glutathione and downstream activation of the metabolic sensor, mechanistic target of rapamycin (mTOR)

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We suggest that when KA is bound strongly in the active site, the binding pocket is not accessible to substrate molecules, subsequently TyrBm is not active

Whilst the majority of investigations into the role of testosterone in muscle adaptive response have been performed in males (reflecting male biology), the importance of circulating concentrations of testosterone in adult women should not be underestimated based on its biological role in the conversion of progesterone to the principal oestrogensoestradiol and oestrone (Cui et al., 2016), a reduction in testosterone generally does not occur independently of other hormones (such as the oestrogens) in females (e.g., following the menopause) (Chakravarti et al., 2007)