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In cholesterol-fed mice, knockdown of FMO3 induced macrophage RCT stimulated by liver X receptor (LXR), thus improving the cholesterol balance and protecting against AS (Warrier et al., 2015)

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Inclusion criteria selected for patients with a diagnosis of epilepsy, an average of at least 2 seizures per month over the preceding 3 months prior to starting MAD, at least 18 years of age at the time of enrollment, having baseline carnitine lab measurement prior to starting MAD, and at least one carnitine lab measurement at a follow-up timepoint