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For example, Lactobacillus plantarum HNU082 alleviates murine colitis by upregulating the tight-junction protein ZO-1 and the mucin MUC2 while modulating microbial diversity (Wu et al., 2022)
Thus, the function of glutamine goes beyond that of a metabolic fuel or protein synthesis precursor

10.1038/nature15541 179 KayagakiN.WebsterJ
But in the case of B12 deficiency, homocysteine may rise beyond normal levels, causing irritation to the cardiovascular system and increasing inflammation