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Additional MS/CPZ-specific downregulated genes further support broad impairment of OL function, including the neuregulin co-receptor ERBB3 (OL survival and differentiation), the citrullinating enzyme PADI2 (myelin basic protein post-translational modification), lipid biosynthesis genes ST3GAL5 and LPCAT2 , the pro-survival receptor LPAR1 , and the differentiation-associated transcription factor E2F3

Additionally, according to the VIP score, the top influential factors in our study were MDA, urea, uric acid, creatinine, TNF-, IL-1, and AFT residue which were sensitive to various treatments and could distinguish AFT treatment from others (Figure 7C)

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