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This absence of IGF-1 stimulation has been consistently demonstrated across multiple studies and dose ranges

Additionally, researchers have developed a range of glutathione-depleting nanodrugs for efficient cancer treatment [49], particularly in addressing chemotherapy resistance in TNBC [50]

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Curcumin prevents the phosphorylation and nuclear translocation of these transcription factors, thereby suppressing the expression of downstream genes such as Survivin, VEGF, and MMP-9 [40, 41]
