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Common side effects are primarily gastrointestinal: Nausea (most common, typically improves with titration) Diarrhea or constipation Abdominal discomfort Reduced appetite (intended therapeutic effect) Serious but rare adverse events include: Pancreatitis Gallbladder disease (especially during rapid weight loss) Boxed warning for thyroid C-cell tumors (observed in rodent studies, not confirmed in humans) From $299 Why These Compounds Do Not Interact Drug interactions occur through several mechanisms: receptor competition, enzyme competition, altered absorption, or pharmacodynamic overlap