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Furthermore, it inhibits EMT and cancer stem cell formation in breast cancer cells to halt metastatic recurrence by disrupting TGF- 1-mediated interactions between TAMs and breast cancer cells [448]
In vivo studies show that muscle-specific triple knockout of FoxO1/3/4 abolishes the induction of 29 atrogenes-including E3 ligases, autophagy mediators, deubiquitinases (e.g., USP14), and proteasome subunits (e.g., Psmd11)-under catabolic stimuli, preserving muscle mass and strength (Sanchez et al., 2014)
C., Lee, S
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