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Both AA-NAT and serotonin availability play a role limiting melatonin production

Blue boxes represent enzymes associated with metabolic pathways that were not detected

Henry SA, Lehmann-Masten V, Gasparini F, Geyer MA, Markou A

Furthermore, whilst loss of C9orf72 in mice models disturbs microglial function, resulting in age-related neuroinflammation, this was not sufficient to cause neurodegeneration in C9orf72 knockout mice (Lall and Baloh, 2017)
