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The risksespecially stomach bleeding and kidney damagemake it essential to use only when truly necessary
oral and intranasal ketamine have a favorable route but a bitter taste and poor bioavailability, whereas subcutaneous and intramuscular routes have greater bioavailability but administration can be painful and have local irritant effects

PRP is an autologous blood fraction that contains a high concentration of platelets and their associated growth factors (GFs), including platelet-derived GF (PDGF), vascular endothelial GF (VEGF), transforming GF- (TGF- ), and epidermal GF (EGF) [6] (Fig
