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Engineered as a synthetic peptide based on the native GIP sequence and modified for extended half-life via fatty acid conjugation, tirzepatide delivers glycemic control, profound weight loss, and cardiometabolic benefits

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This and many other hitherto uncharacterised factors induce accumulation of pathogenic inclusions differently termed as Lewy bodies in neurons of PD patients (Marotta et al., 2021) or glial cytoplasmic inclusions in oligodendrocytes of Multiple System Atrophy (MSA) patients (Reddy and Dieriks, 2022)