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Following OA induction, the rabbits were randomly divided into four groups with 8 subjects, each receiving a different weekly intra-articular treatment starting four weeks after the first collagenase injection

After that, packaging containers are shifted to filling station and filled with precise amount of sterile preparation

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Histology may reveal epidermal thinning, vacuolar changes and nuclear elongation of keratinocytes, increases in the number of melanocytes in basal layers, and the presence of numerous melanophages in the papillary dermis.3,9 Electron microscopy will show intracytoplasmic desmosomes, numerous aggregated bundles of tonofilaments in the cytoplasm of keratinocytes, and highly condensed keratohyalin granules.10 In the present case, the results of the 2 histological studies carried out were not consistent with the findings described above and were, rather, indicative of an adverse drug reaction